Bitoshi lets you accept USDC and USDT on Ethereum (ERC-20), the most widely supported chain - or accept card payments that settle to you as Ethereum stablecoins in your own wallet, non-custodially.
Ethereum for maximum compatibility
Ethereum has the broadest wallet and exchange support. Gas fees are higher than Polygon or BSC, so it suits larger payments where compatibility matters most. Settlement is non-custodial to your own ERC-20 wallet.